文献：Slatkovska L et al.Effect of 12 Months of Whole-Body Vibration Therapy on Bone Density and Structure in Postmenopausal Women: A Randomized Trial.Ann Intern Med. 2011 Nov 15;155(10):668-79.

　健康な閉経後女性202人を対象に、12カ月間の全身振動（WBV）療法の効果を無作為化対照試験で検討。骨梁容積骨密度のベースラインからの変化はWBVの90Hz群で0.4mg/cm3、30Hz群で−0.1mg/cm3、対照群で−0.2mg/cm3だった。全身振動療法は骨密度や骨の構造に有意な影響を与えなかった。

Effect of 12 Months of Whole-Body Vibration Therapy on Bone Density and Structure in Postmenopausal Women

A Randomized Trial

+ Author Affiliations

1. From University Health Network, Mount Sinai Hospital, and University of Toronto, Toronto, and McMaster University, Hamilton, Ontario, Canada.

Abstract

Background: Although data from studies in animals demonstrated beneficial effects of whole-body vibration (WBV) therapy on bone, clinical trials in postmenopausal women showed conflicting results.

Objective: To determine whether WBV improves bone density and structure.

Design: A 12-month, single-center, superiority, randomized, controlled trial with 3 parallel groups. (ClinicalTrials.gov registration number: NCT00420940)

Setting: Toronto General Hospital, Ontario, Canada.

Participants: 202 healthy postmenopausal women with bone mineral density (BMD) T-scores between ?1.0 and ?2.5 who were not receiving prescription bone medications.

Intervention: Participants were randomly assigned to 1 of 3 groups (1:1:1 ratio) by using a block-randomization scheme and sealed envelopes. They were asked to stand on a low-magnitude (0.3g) 90-Hz or 30-Hz WBV platform for 20 minutes daily or to serve as control participants; all participants received calcium and vitamin D.

Measurements: Bone outcome assessors, who were blinded to group assignment, determined trabecular volumetric BMD and other measurements of the distal tibia and distal radius with high-resolution peripheral quantitative computed tomography and areal BMD with dual-energy x-ray absorptiometry at baseline and at 12 months.

Results: 12 months of WBV therapy had no significant effect on any bone outcomes compared with no WBV therapy. For the primary outcome of tibial trabecular volumetric BMD, mean change from baseline was 0.4 mg/cm3 (95% CI, ?0.4 to 1.2 mg/cm3) in the 90-Hz WBV group, ?0.1 mg/cm3 (CI, ?1.0 to 0.8 mg/cm3) in the 30-Hz WBV group, and ?0.2 mg/cm3 (CI, ?1.1 to 0.6 mg/cm3) in the control group (P = 0.55). Changes in areal BMD at the femoral neck, total hip, and lumbar spine were also similar among the groups. Overall, low-magnitude WBV at both 90 and 30 Hz was well-tolerated.

Limitations: Adherence to WBV ranged from 65% to 79%. Double-blinding was not possible.

Conclusion: Whole-body vibration therapy at 0.3g and 90 or 30 Hz for 12 months did not alter BMD or bone structure in postmenopausal women who received calcium and vitamin D supplementation.

Primary Funding Source: Physicians' Services Incorporated Foundation.

2011年11月17日　提供：Ann Intern Med